Heroes[]
- Danny Trejo as Gashon Cansaker
- Milo Ventimigilia as Price Rocks
- Erik King as Admiral Atom
- Danny McBride as Dylan T. Best
- Daniel Bruhl as Reedman
- Tim Blake Nelson as Jay J. Johnson
- Rainn Wilson as Kahar Zamet
- Channing Tatum as Just Jeulin
Supporting Cast[]
- Bradley Cooper as Boba Bactapack
- Nathan Fillion as Oreo Cakestir
- Felicia Day as Rylie Tano
- Amy Lee as Mirta Meta
- Halle Berry as Darth Nina
- Justin Timberlake as Epic Ares
- Matthew Gray Gubler as Kane Wrathblaze
- Peter Dinklage as Gleb Kaminer
- Emma Stone as Lexi Boop
- Uma Thurman as Xalandra Nova
- Chin Han as Daniel Greenpulser
- Willem Dafoe as Jarat Salas
- Aaron Paul as Bladez
- Zac Efron as Ace Breao
- Ron Jeremy as Male Stripper
- Nick Swardson as Rygan Flareslice
- Kat Dennings as Arianna
- Logan Lerman as Law
- Arianna Grande as Luna
- Andrew Garfield as Redge Powerstunner
- Idris Elba as Tal Novik
- Ryan Reynolds as Alvin Novik
- Charlie Sheen as ChanServ
- Zack Galifanakis as Cod10k
- Jesse Eisenberg as Vein
- Bill Murray as Gashdad
- Betty White as Gashmom
- Paul Dano as Crit
- James Spader as Pelt
- Jack Coleman as Callofduty4
- Michael Fassbender as Altaïr
Villains[]
- Matt Smith as Renaldo lon
- James Franco as Axrik / Blast Radum
- Tom Selleck as Wuher
- Harrison Ford as Bane
- Ken Jong as Knight
- Jack Gleeson as Evan Alde
- Mark Ruffalo as Tey Voro
- Elijah Wood as Anakin Xenobomber
- Crispin Glover as Tiger Assassin
- Michael Cera as Benjamin Draggo
- Sandra Bullock as Sarria
- Ryan Sheckler as Kryyton
- Michael Emerson as Fishy
- Christopher Heyerdahl as Fox
- Woody Harrelson as Grif / Bright Starsong
- John Goodman as Adam Heart
- Liam Neeson as Green Wizard
- Taylor Lautner as Evanf
- Jake Lloyd as Casey Layman
- Michael Masse as Invisi
- Hugo Weaving as Dex Extra
- Miley Cyrus as LexiTano
- Anne Hathaway and Toby Turner as Boushh
- Robin Lord Taylor as S4WDuST
- Dane DeHaan as EV1SC3RAT1ON
- Logan Paul as Clonefanatic / Ash